Induction of Connective Tissue Growth Factor by Angiotensin II
نویسندگان
چکیده
منابع مشابه
Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways.
OBJECTIVE Angiotensin II is recognized as one of the major mediators of cardiovascular pathology. Because connective tissue growth factor (CTGF) is involved in the pathophysiologic processes underlying fibrotic diseases, its regulation by angiotensin II was investigated. METHODS AND RESULTS In the 2-kidney, 1-clip model of renovascular hypertension, increased expression of CTGF was detectable...
متن کاملConnective tissue growth factor is a mediator of angiotensin II-induced fibrosis.
BACKGROUND Angiotensin II (Ang II) participates in the development of fibrosis during vascular damage. Connective tissue growth factor (CTGF) is a novel fibrotic mediator. However, the potential link between CTGF and Ang II has not been investigated. METHODS AND RESULTS In vivo Ang II effects were studied by systemic infusion into normal rats to evaluate CTGF and extracellular matrix protein ...
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AIMS Remodelling of the extracellular matrix (ECM) plays an important role in the production of arrhythmogenic substrate for atrial fibrillation (AF), and is considered to be promoted by the connective tissue growth factor (CTGF). Our objective was to assess the relationship between CTGF and ECM synthesis, and the effect of olmesartan on these processes. METHODS AND RESULTS Fifteen canine AF ...
متن کاملConnective tissue growth factor expression and induction by transforming growth factor- is abrogated by simvastatin via a Rho signaling mechanism
Watts, Keira L., and Monica A. Spiteri. Connective tissue growth factor expression and induction by transforming growth factoris abrogated by simvastatin via a Rho signaling mechanism. Am J Physiol Lung Cell Mol Physiol 287: L1323–L1332, 2004. First published August 6, 2004; doi:10.1152/ajplung.00447.2003.—Connective tissue growth factor (CTGF), a potent profibrotic mediator, acts downstream an...
متن کاملInduction of Connective Tissue Growth Factor by Activation of Heptahelical Receptors
Expression of connective tissue growth factor (CTGF) was induced in renal mesangial cells by activation of heptahelical receptors by serotonin (5-HT) and lysophosphatidic acid (LPA). Induction of CTGF mRNA was transient with maximal expression after 1 to 2 h, whereas induction of CTGF by transforming growth factor beta (TGF-b) increased over time. In contrast to the induction of other early res...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2003
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000092913.60428.e6